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| Karimzadeh,Latifeh; Nabiuni,Mohammad; Kouchesfehani,Homa Mohseni; Adham,Hamed; Bagheri,Amir; Sheikholeslami,Azar. |
| Background : Polycystic ovarian syndrome (PCOS) is a low-grade inflammatory disease characterized by hyperandrogenemia, hirsutism, chronic anovulation and vascular disorder. Interleukin-6 (IL-6), cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) are triggered by inflammatory stimuli and lead to angiogenesis and pathogenesis of the ovary. Honeybee venom (HBV) contains an array of biologically active components possessing various pharmaceutical properties. This study was designed to assess the possibility of HBV application as an anti-inflammatory therapeutic agent to suppress levels of the main inflammatory mediators IL-6, COX-2 and VEGF. To induce PCOS, 1 mg of estradiol valerate (EV) per 100 g of body weight was subcutaneously (SC)... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Polycystic ovarian syndrome; Honeybee venom; Interlukin-6; Cyclooxygenase-2; Vascular endothelial growth factor. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992013000100317 |
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